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- 产品名称： Research Grade Nivolumab ( 纳武单抗 )
- 产品货号： CSD00292
- 货期： 现货
- 价格与订购： 2480
- 数量：
库存： 10
- 规格： 100μg
- 产品信息
- 如何订购
货号（Catalog No.）
CSD00292
通用名INN
Nivolumab
纯度(Purity)
>95%
浓度( Concentration)
1mg/ml
Formulation
PBS buffer PH7.5
Source
CHO cells
内毒素(Endotoxin level)
Please contact with the lab for this information.
产品描述(Description)
Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer.
别名(Alternative names)
BMS-936558,MDX-1106,ONO-4538
靶点;物种(Specificity target name;species)
PDCD1/PD1/CD279[Homo sapiens]
活性研究（体外/体内研究）(Activity in vitro)
Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus.
种类(Species)
Homo sapiens
受体鉴定(Receptor identification)
IgG4-kappa
分子量(MV)
143599.09 Da
CAS
946414-94-4
存储条件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Note
For research use only .
地 址：
产品销售：
E - mail ：
邮 编：
Amily
