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- 产品名称： SR8278
- 产品货号： CS7837
- 货期： 现货
- 价格与订购： 960
- 数量：
库存： 100
- 规格： 1mg 10mg 1g
- 产品信息
- 如何订购
产品描述
SR8278 is an REV-ERBα antagonist(EC50 = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112
靶点活性
REV-ERBα
体外活性
SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells[1]
参考文献
1. Kojetin D , Wang Y , Kamenecka T M , et al. Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB[J]. Acs Chemical Biology, 2011, 6(2):131-134.2. Dong D , Sun H , Wu Z , et al. A validated ultra-performance liquid chromatography-tandem mass spectrometry method to identify the pharmacokinetics of SR8278 in normal and streptozotocin-induced diabetic rats[J]. Journal of Chromatography B, 2016, 1020:142-147.
纯度
99.44%
分子量
361.48
分子式
C18H19NO3S2
CAS No
1254944-66-5
存储
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
溶解度
DMSO: 10mg/ml(27.66mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Note
For research use only .
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